TARDBP antibody (10R-1095)

Mouse monoclonal TARDBP antibody

Synonyms Monoclonal TARDBP antibody, Anti-TARDBP antibody, TDP-43 antibody, TAR DNA binding protein antibody, TAR DNA binding protein antibody, ALS10 antibody, TAR DNA-binding protein 43 antibody, ALS10 antibody, TDP-43 antibody, TAR DNA-binding protein 43 antibody, TDP43 antibody, Anti TARDBP antibody , TARDBP antibody, TDP43 antibody
Specificity Human
Cross Reactivity To be determined by end-user.
Applications ELISA, IHC, WB
Immunogen TARDBP antibody was raised in mouse using recombinant human TARDBP (1-260aa) purified from E. coli as the immunogen.

Images

Western Blot analysis of TARDBP antibody (10R-1095)

Cell lysates of HeLa(20 ug) were resolved by SDS-PAGE, transferred to nitrocellulose membrane and probed with anti-human TARDBP (1:1,000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Specifications

Host Mouse
Clone k1B8
Isotype IgG1 kappa
Source Anti-human TARDBP antibody, clone k1B8, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TARDBP protein.
Method of Purification TARDBP antibody was purified by protein-G affinity chromatography
Form & Buffer Supplied as a liquid in PBS, pH 7.4, with 0.1% NaN3.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1:1,000-1:2,000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein. TARDBP was identified as the disease accumulating protein in patients with frontotemporal lobar degeneration (FTLD) with ubiquitin inclusions (FTLD-U) and in amyotrophic lateral sclerosis (ALS). TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. In addition, this protein regulates alternate splicing of the cystic fibrosis transmembrane receptor (CFTR) gene.

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Images

  • Western Blot analysis of TARDBP antibody (10R-1095) | Cell lysates of HeLa(20 ug) were resolved by SDS-PAGE, transferred to nitrocellulose membrane and probed with anti-human TARDBP (1:1,000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Availability: In stock

Price: €277.55
Size: 100 ul
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