Tau antibody (70R-10637)
Affinity purified Chicken polyclonal Tau antibody
Overview
Overview
| Synonyms | Polyclonal Tau antibody, Anti-Tau antibody, phospho-tau antibody, phospho tau antibody, NFT antibody, PHF antibody |
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| Applications | ICC, IHC, WB |
| Immunogen | Tau antibody was raised in Chicken using two synthetic peptide (Human NP_05819 and Mouse P01637) / keyhole limpet hemocyanin (KLH) conjugates corresponding to different and nonphosphorylated regions of the TAU gene product as the immunogen. |
Images
Immunohistochemical staining using Tau antibody (70R-10637)
Tissue section through the hippocampus of a patient diagnosed with Alzheimer’s disease. Note the high concentrations of intracellular tau immunoreactivity in pyamidal neurons (brown), as well as lower concentrations of reaction product in the neuropil. The slide was counterstained with hemotoxylin. Picture courtesy of Dr. Randy Woltjer, Oregon Health & Sciences University.
Specifications
| Host | Chicken |
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| Method of Purification | Tau antibody was purified by affinity chromatography. |
| Form & Buffer | Supplied in liquid form in 10 mM PBS buffer, pH 7.2, with 0.02% sodium azide added as a preservative. |
| Concentration | 100 ug/ml |
Usage & Assay Information
| Usage Recommendations | ICC: 1:10000-1:20000; IHC: 1:10000-1:20000; WB: 1:20000-1:50000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. Protect from light. |
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General Information
| Biological Significance | Tau proteins belong to the family of microtubule-associated proteins. They are mainly expressed in neurons where they play an important role in the assembly of tubulin monomers into microtubules to constitute the neuronal microtubules network. Microtubules are involved in maintaining the cell shape and serve as tracks for axonal transport. |
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