TBCA protein (30R-1333)
Purified recombinant Human TBCA protein
|Synonyms||Tubulin cofactor a., Co chaperonin associated with a & b tubulin protein, Tubulin folding cofactor A protein, Cofactor A protein, chaperonin cofactor a protein, TCP1 chaperonin cofactor A protein, TBCA protein, tubulin specific chaperone a protein, Tubulin folding cofactor A CFA protein|
Coomassie Blue stained SDS-PAGE of TBCA protein (30R-1333)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-108 amino acids: MADPRVRQIK IKTGVVKRLV KEKVMYEKEA KQQEEKIEKM RAEDGENYDI KKQAEILQES RMMIPDCQRR LEAAYLDLQR ILENEKDLEE AEEYKEARLV LDSVKLEA|
|Grade & Purity||> 95% pure|
|Molecular Weight||12.8 kDa (108aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 7.5, containing 1 mM DTT, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Tubulin folding cofactor A, also known as TBCA, is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin in a quasi-native confirmation. This protein is essential for cell viability and its knockdown produces a decrease in the amount of soluble tubulin, modifications in microtubules and G1 cell cycle arrest. Recombinant human TBCA protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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