TBE NS1 protein (80-1545)
Purified Recombinant TBE NS1 protein (His tag)
Overview
Overview
| Synonyms | TBE NS1 antigen, Tick-borne encephalitis NS1 protein, Tick-borne encephalitis protein |
|---|---|
| Species | Viral |
| Protein Type | Recombinant |
Specifications
| Expression System | 293 cells |
|---|---|
| Grade & Purity | > 90% pure |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied in DPBS, pH 7.4, 0.2µm filter sterilised |
| Concentration | 500 ug/ml |
Storage & Safety
| Storage | Store at -80 deg C |
|---|
General Information
| Product Use | TBE NS1 protein for use in the research laboratory |
|---|---|
| Biological Significance | TBE virus is transmitted to humans through the bite of an infected tick of the Ixodes species, primarily I. ricinus (European subtype) or I. persulcatus (Siberian and Far Eastern subtypes). The virus is maintained in discrete areas of deciduous forests. Ticks act as both vector and virus reservoir, and small rodents are the primary amplifying host. TBE can also be acquired by ingesting unpasteurized dairy products (such as milk and cheese) from infected goats, sheep, or cows. TBE virus transmission has infrequently been reported through laboratory exposure and slaughtering viremic animals. Direct person-to-person spread of TBE virus occurs only rarely, through blood transfusion or breastfeeding. |
| Implications in Disease | The range of clinical manifestations can be observed following infection by any of the TBE virus subtypes. Biphasic symptomatology (fever then neurological disorders) is frequent after infection with the European or Western TBE subtype. Infections by the Far-eastern TBE subtype are generally more severe and the case-fatality rate is higher. The Siberian subtype in children could be responsible for chronic encephalitis. In the majority of patients infected with the European TBE virus, only an early (viremic) phase is experienced; symptoms are nonspecific and may include fever, malaise, anorexia, muscle aches, headache, nausea, and/or vomiting. After about 8 days of remission, a second phase of disease occurs in 20% to 30% of patients. These patients may experience a clinical illness that involves the central nervous system with symptoms of meningitis (e.g., fever, headache, and a stiff neck), encephalitis (e.g., drowsiness, confusion, sensory disturbances, and/or motor abnormalities such as paralysis), or meningoencephalitis. |
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