TBE NS1 protein (80-1545)

Purified Recombinant TBE NS1 protein (His tag)

Synonyms TBE NS1 antigen, Tick-borne encephalitis NS1 protein, Tick-borne encephalitis protein
Species Viral
Protein Type Recombinant

Specifications

Expression System 293 cells
Grade & Purity > 90% pure
Tag/Conjugate His tag
Form & Buffer Supplied in DPBS, pH 7.4, 0.2µm filter sterilised
Concentration 500 ug/ml

Storage & Safety

Storage Store at -80 deg C

General Information

Product Use TBE NS1 protein for use in the research laboratory
Biological Significance TBE virus is transmitted to humans through the bite of an infected tick of the Ixodes species, primarily I. ricinus (European subtype) or I. persulcatus (Siberian and Far Eastern subtypes). The virus is maintained in discrete areas of deciduous forests. Ticks act as both vector and virus reservoir, and small rodents are the primary amplifying host. TBE can also be acquired by ingesting unpasteurized dairy products (such as milk and cheese) from infected goats, sheep, or cows. TBE virus transmission has infrequently been reported through laboratory exposure and slaughtering viremic animals. Direct person-to-person spread of TBE virus occurs only rarely, through blood transfusion or breastfeeding.
Implications in Disease The range of clinical manifestations can be observed following infection by any of the TBE virus subtypes. Biphasic symptomatology (fever then neurological disorders) is frequent after infection with the European or Western TBE subtype. Infections by the Far-eastern TBE subtype are generally more severe and the case-fatality rate is higher. The Siberian subtype in children could be responsible for chronic encephalitis. In the majority of patients infected with the European TBE virus, only an early (viremic) phase is experienced; symptoms are nonspecific and may include fever, malaise, anorexia, muscle aches, headache, nausea, and/or vomiting. After about 8 days of remission, a second phase of disease occurs in 20% to 30% of patients. These patients may experience a clinical illness that involves the central nervous system with symptoms of meningitis (e.g., fever, headache, and a stiff neck), encephalitis (e.g., drowsiness, confusion, sensory disturbances, and/or motor abnormalities such as paralysis), or meningoencephalitis.

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Price From: Price: €397.55
Price From: Price: €397.55
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