TG3 protein (His tag) (80-1386)
Purified recombinant Transglutaminase 3 (TG3) protein (His tag)
Overview
Overview
| Synonyms | Transglutaminase 3 protein, TG3 protein, TG(E) protein, TGase-3 protein, Protein-glutamine-gamma-glutamyltransferase protein |
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| Species | Human |
| Protein Type | Recombinant |
Specifications
| Residues | 1-693 aa |
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| Expression System | Baculovirus |
| Grade & Purity | > 90% pure |
| Method of Purification | Purified using proprietary chromatographic techniques |
| Molecular Weight | 79 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied in 50mM Na2PO4 pH 8.0, 150mM NaCl, 10% glycerol, 2mM DTT and 1mM EDTA |
Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | TG3 catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. |
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| Expression | Expression levels are increased in relation to calcium ion concentration. Tissue and Cell Localization: TG3 proteins are widely distributed in the cytoplasm. |
| Implications in Disease | Anti-transglutaminase antibodies are found in celiac disease and may play a role in the small bowel damage in response to dietary gliadin that characterises this condition. |
| Post-Translational Modifications | TG3 is activated by proteolytic processing. In vitro activation is commonly achieved by cleavage with dispase, a neutral bacterial protease. Dispase cleavage site was proposed to lie between Ser-470 and Ser-471. |
| Database Links | Entrez Gene: 7053 Human, Omim: 600238 Human, SwissProt: Q08188 Human, Unigene: 2022 Human |
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