TGF beta antibody (10R-6686)

Rat monoclonal TGF beta antibody

Synonyms Monoclonal TGF beta antibody, Anti-TGF beta antibody, Transforming Growth Factor beta 1 antibody, TGF beta antibody, TGF-b1 antibody, TGFbeta1 antibody, Transforming Growth Factor beta 1 antibody, TGFbeta1 antibody, TGF-b1 antibody, Anti TGF beta antibody
Specificity Mouse
Applications Functional Assay
Assay Information Currently there is no reliable bioassay available for recombinant mouse IL-31.

Images

ELISA Assay using TGF beta antibody (10R-6686)

Standard curve of TGF beta antibody in ELISA. Recombinant cytokine standard concentration in pg/ml.

Specifications

Host Rat
Clone TB2F
Isotype IgG2a kappa
Method of Purification TGF beta antibody was purified by affinity chromatography.
Form & Buffer Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer.

Storage & Safety

Storage Store at 2-8 deg C. Do not freeze. Protect from light.

General Information

Biological Significance The TB2F antibody reacts with Transforming Growth Factor-beta, a pleiotropic cytokine, exists in five isoforms, known as TGF-beta1-5. Homologies between isoforms range from 70-80% but no homology exists to TGF- alpha. TGF-beta1 is ubiquitous and the most abundant form found in lymphoid organs, while other isoforms are expressed in a more restricted distribution. The biologically active state of all isoforms are disulfide-linked homodimers. The heat- and acid- stable monomeric subunits have a length of 112 amino acids. The isoforms of TGF-beta arise by proteolytic cleavage of longer precursors the isoforms are derived from the carboxyterminal ends of these precursors. Isoforms isolated from different species are evolutionarily closely conserved and have sequence identities on the order of 98%. Mature human, porcine, simian, chicken and bovine TGF-beta1 are identical and differ from mouse TGF-beta1 in a single amino acid. TGF-beta1 is produced in very high levels by platelets. Other cellular sources of TGF-beta1 include macrophages, lymphocytes, endothelial cells, chondrocytes, and leukemic cells. TGF-beta1 secretion can be induced by steroids, retinoids, EGF, NGF, vitamin D3, and IL-1. Activities of TGF-beta1 include inhibition of cell growth for inhibitor for normal and transformed epithelial cells, endothelial cells, fibroblasts, neurons, and lymphoid cells and other hematopoietic cell types. TGF-beta1 inhibits the proliferation of T cells and NK cells and downregulates the activities of activated macrophages. TGF-beta1 blocks the anti-tumor activity of IL-2 ? bearing lymphokine-activated killer cells. Recently, TGF-beta1 has been found to have a critical role in the development of regulatory T cells. Dendritic cells exposed to tumors have been reported to secrete TGF-beta1 and stimulate expansion of natural T reg cells. Moreover, TGF-beta1 has been shown to act as a costimulatory factor for expression of Foxp3, leading to the differentiation of CD4+CD25+ Treg cells from peripheral CD4+CD25- progeny. TGF-beta-induced regulatory T cells have been termed Ti-Treg.

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  • ELISA Assay using TGF beta antibody (10R-6686) | Standard curve of TGF beta antibody in ELISA. Recombinant cytokine standard concentration in pg/ml.

Availability: In stock

Price: €114.52
Size: 50 ug
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