THPO protein (His tag) (80R-4189)

Recombinant Human THPO protein (His tag)

Synonyms Thrombopoietin isoform 1 protein, MGDF protein, MKCSF protein, ML protein, MPLLG protein, THCYT1 protein, TPO protein
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Images

SDS-PAGE analysis of THPO protein (His tag) (80R-4189)

Figure annotated with amount of protein analysed and % SDS PAGE gel.

Specifications

Residues 22-353 amino acids: SPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNELPNRTSG LLETNFTASA RTTGSGLLKW QQGFRAKIPG LLNQTSRSLD QIPGYLNRIH ELLNGTRGLF PGPSRRTLGA PDISSGTSDT GSLPPNLQPG YSPSPTHPPT GQYTLFPLPP TLPTPVVQLH PLLPDPSAPT PTPTSPLLNT SYTHSQNLSQ EGLEHHHHHH
Expression System Insect cells
Grade & Purity > 85% pure
Molecular Weight 36.5 kDa
Tag/Conjugate His tag
Form & Buffer Supplied as liquid in PBS, pH 7.4 containing 10% glycerol.
Concentration 250 ug/ml

Storage & Safety

Storage Store at 4 deg C short term. Aliquot and store at -70 deg C for long term and avoid repeated freeze thaw cycles
Endotoxin Levels < 1.0 EU/ug protein

General Information

Biological Significance THPO (Thrombopoietin), also known as megakaryocyte growth and development factor (MGDF), is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets. It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Megakaryocytopoiesis is the cellular development process that leads to platelet production. THPO is a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Recombinant human THPO, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

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Images

  • SDS-PAGE analysis of THPO protein (His tag) (80R-4189) | Figure annotated with amount of protein analysed and % SDS PAGE gel.

Availability: In stock

Price: €306.75
Size: 50 ug
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