Thrombomodulin protein (80R-4191)
Purified recombinant Thrombomodulin protein
Overview
Overview
| Synonyms | Thrombomodulin protein, AHUS6 protein, CD141 protein, CD141 antigen, Fetomodulin protein, THRM protein, TM protein, TRBM protein, THBD protein |
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| Species | Human |
| Protein Type | Recombinant |
Specifications
| Residues | Expression Region:19-515aa; |
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| Expression System | E.coli |
| Grade & Purity | > 90% pure |
| Form & Buffer | Supplied in a Tris-based buffer with 50% glycerol |
Storage & Safety
| Storage | Store at -20 deg C, for extended storage, conserve at -20 deg Cor -80 deg C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 deg Cfor up to one week. |
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General Information
| Biological Significance | Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THPH12). |
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