Thrombopoietin protein (30R-AT017)

Purified recombinant Human Thrombopoietin protein

Synonyms TPO protein, THPO protein, MGDF protein, c-MPL Ligand protein, Megakaryocyte colony-stimulating factor protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of Thrombopoietin protein corresponding to amino acids SPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNEL.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 18.6 kDa
Form & Buffer Lyophilized from 0.1% TFA buffer. Reconstitute in water to a concentration of 0.5 - 1.0 mg/ml.

Usage & Assay Information

Bioactivity The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be approximately 1.0 ng/ml, corresponding to a specific activity of approximately 1 x 10^6 units/mg.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and Mouse TPO exhibits cross-species reactivity.

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Availability: In stock

Price: €211.69
Size: 10 ug
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