TLR4 antibody (70R-11717)
Rabbit polyclonal TLR4 antibody
Overview
Overview
| Synonyms | Polyclonal TLR4 antibody, anti-TLR4 antibody, Toll-like receptor 4 antibody, TOLL antibody, TLR-4, TLR 4 antibody, ARMD10 antibody, TLR-4 antibody, TLR 4, CD284 antibody, TLR4, hToll antibody |
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| Cross Reactivity | Human |
| Applications | FC, WB |
| Immunogen | TLR4 antibody was raised in Rabbit using recombinant human TLR4 as the immunogen. |
Images
Western Blot analysis using TLR4 antibody (70R-11717)
Western blot analysis of TLR4 in transfected HRK293 cells.
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | TLR4 antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in PBS buffer, pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal |
| Concentration | 200 ug/ml |
Usage & Assay Information
| Usage Recommendations | WB: 0.5-4 ug/ml |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | TLR4 is a mammalain homologue of the Drosophila toll protein. The human TLR4 is a type-1 transmembrane protein containing 799 amino acid residues. The extracellular domain has leucine-rich repeats and the intracellular domain is similar to that of IL-1 receptor. TLR4 is a receptor for lipopolysaccharide. In mice that are genetically tolerant to endotoxin, mutations have been identified in the intracellular domain of TLR4 that abolish LPS responsiveness. TLR4 uses a mechanism similar to that of the IL-1 receptor for signal transduction that leads to activation of NF-kB. |
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