TNF alpha antibody (10R-T114a)
Mouse monoclonal TNF alpha antibody
Overview
Overview
| Synonyms | Monoclonal TNF alpha antibody, Anti-TNF alpha antibody, TNFa antibody, Necrosin antibody, Anti TNF alpha antibody, TNF-alpha antibody, TNF-a antibody, Necrosin antibody, Tumor Necrosis Factor antibody, TNF alpha antibody, Tumor Necrosis Factor antibody, Cytotoxin antibody, Cachectin antibody, Differentiation-inducing factor antibody, DIF antibody, DIF antibody, TNF-alpha antibody, Differentiation-inducing factor antibody, TNF-a antibody, TNFa antibody, TNFSF2 antibody, TNFSF2 antibody, Cytotoxin antibody, Cachectin antibody |
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| Specificity | Human TNF-alpha |
| Cross Reactivity | To be determined by end-user |
| Applications | ELISA, Inhibition, WB |
| Immunogen | TNF alpha antibody was raised in mouse using highly pure recombinant human TNF-alpha as the immunogen. |
Specifications
| Host | Mouse |
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| Clone | M26 |
| Isotype | IgG1 kappa |
| Molecular Weight | 17.3 kDa (predicted detection band MW) |
| Form & Buffer | Lyophilized from PBS. Reconstitute in sterile water to a concentration 1.0 mg/ml. |
Usage & Assay Information
| Usage Recommendations | ELISA: 2-4 ug/ml, Inhibition: |
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Storage & Safety
| Storage | Store at -20 deg C until reconstitution. Following reconstitution product may be stored at 4 deg C in the short term. For long term storage aliquot and freeze at -20 deg C. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | TNF-alpha is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-alpha is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-alpha also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. |
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