TNF alpha protein (30R-AT013)

Purified recombinant Human TNF alpha protein

Synonyms TNF-a protein, DIF protein, TNFa protein, Cachectin protein, Differentiation-inducing factor protein, Cytotoxin protein, Tumor Necrosis Factor protein, Necrosin protein, TNFSF2 protein, TNF-alpha protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of TNF alpha protein corresponding to amino acids MLRSSSQNSS DKPVVHVVAN HQAEEQLEWL SQRANALLAN GMDLKDNQLV VPADGLYLIY SQVLFKGQGC PDYVLLTHTV SRFATSYQEK VSLLSAIKSP CPKDTPEGAE LKPWYEPMYL GGVSQLEKGD LLSAEVNLPK YLDITESGQV YFGVIAL.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 17.3 kDa
Form & Buffer Lyophilized from PBS, pH 7.1. Reconstitute in water to a concentration of 0.1 - 1.0 mg/ml.

Usage & Assay Information

Bioactivity The ED50 as determined by the cytolysis of Mouse L929 cells in the presence of actinomycin D is 5 x 10^7 units/mg.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance TNF-alpha is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-alpha is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-alpha also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes.

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Availability: In stock

Price: €211.69
Size: 20 ug
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