Monoclonal Topoisomerase II antibody, Anti-Topoisomerase II antibody, Anti Topoisomerase II antibody, Topoisomerase II alpha antibody, Topoisomerase II antibody, Topoisomerase II alpha antibody, Topoisomerase II beta antibody, Topoisomerase II beta antibody
Specificity
Human
Cross Reactivity
Mouse, rat
Applications
WB
Immunogen
Topoisomerase II antibody was raised in mouse using recombinant human DNA-topoisomerase IIa (N-terminal fragment) as the immunogen.
Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
General Information
Biological Significance
Type II topoisomerases cut both strands of the DNA helix simultaneously in order to unwind it. The energy required for this is the hydrolysis of ATP, unlike type I topoisomerase, which is thermodynamically favored. In this process, these enzymes change the linking number of circular DNA by +/-2.