TPO protein (30R-2579)

Purified recombinant Human TPO protein

Synonyms Myeloproliferative leukemia virus oncogene ligand protein, Megakaryocyte growth and development factor protein, MGC163194 protein, TPO protein, THPO protein, MGDF protein, Megakaryocyte colony-stimulating factor protein, ML protein, MPLLG protein, MKCSF protein, C-mpl ligand protein
Species Human
Protein Type Recombinant

Specifications

Expression System E.coli
Grade & Purity > 98% pure
Method of Purification TPO protein was purified using a a proprietary chromatographic technique.
Form & Buffer Supplied in lyophilized form with no additives

Usage & Assay Information

Bioactivity The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found < 1 ng/ml, corresponding to a specific activity of > 1 x 10^6 IU/mg

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels <0.1 ng/ug

General Information

Biological Significance TPO stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets.

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