Trem1 antibody (70R-14123)

Affinity purified Rabbit polyclonal Trem1 antibody

Synonyms Polyclonal Trem1 antibody, Anti-Trem1 antibody, Trem-1 antibody, Triggering receptor expressed on myeloid cells 1 antibody, Trem 1, Trem1, Trem-1, Trem 1 antibody
Applications IHC-F, IHC-P, WB
Immunogen Trem1 antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence in the middle of Rabbit Trem1 as the immunogen

Images

Immunohistochemical staining using Trem1 antibody (70R-14123)

Immunohistochemistry of paraffin-embedded section of Rat Spleen Tissue

Specifications

Host Rabbit
Isotype IgG
Method of Purification Trem1 antibody was purified by affinity chromatography
Form & Buffer Supplied in lyophilized form

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by the end user

Storage & Safety

Storage Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.

General Information

Biological Significance Trem1 is encoded by the Trem1 gene. The expression of Trem1 is in monocytes and neutrophils but not in lymphocytes, dendritic cells, or other cell types. Trem1 is a 30-kD glycoprotein that is reduced to 26 kD by deglycosylation, in agreement with the predicted molecular mass. The Trem1 gene which contains 4 exons maps to chromosome 6p21.1, within a TREM gene cluster and the mouse Trem1 gene maps to chromosome 17 in a region that shows homology of synteny to human chromosome 6. The expression of Trem1 is upregulated by stimulation with lipopolysaccharide (LPS), gram-negative bacteria, and fungi. Cross-linking of Trem1 on neutrophils induces interleukin-8 (IL8) and myeloperoxidase secretion, while cross-linking on monocytes induces not only secretion of IL8 but also of monocyte chemotactic protein-1 (MCP1, or SCYA2) and tumor necrosis factor (TNF); MCP1 and TNF secretion could be further upregulated by LPS-mediated priming. Trem1 engagement also induces upregulation of adhesion molecules (e.g. ITGB1) and costimulatory molecules (e.g., CD40). Trem1 is associated with DAP12 (TYROBP), a molecule frequently associated with activating receptors.

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Images

  • <div><font face=Calibri size=2>Immunohistochemical staining using Trem1 antibody (70R-14123)</font></div>     | Immunohistochemistry of paraffin-embedded section of Rat Spleen Tissue
  • <div><font face=Calibri size=2>Western Blot analysis using Trem1 antibody (70R-14123)</font></div>     | Lane 1: Recombinant Mouse TREM1 Protein 10ng; Lane 2: Recombinant Mouse TREM1 Protein 5ng; Lane 3: Recombinant Mouse TREM1 Protein 2.5ng

Availability: In stock

Price: €220.86
Size: 100 ug
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