TrkA antibody (20R-TR013)

Rabbit polyclonal TrkA antibody

Synonyms Polyclonal TrkA antibody, Anti-TrkA antibody, Trk-A antibody, Trk A antibody
Specificity Rat
Cross Reactivity Human, mouse
Applications ICC, IP, WB
Immunogen TrkA antibody was raised in rabbit using recombinant protein corresponding to extracellular domain of rat TrkA receptor as the immunogen.

Images

Western blot analysis using TrkA antibody (20R-TR013)

Western blot analysis of EGF-stimulated A431 cel lysate probed with anti-TrkA (2 ug/ml)

Specifications

Host Rabbit
Isotype IgG
Method of Purification TrkA antibody was purified by Protein A chromatography.
Molecular Weight 140 kDa (predicted detection band MW)
Form & Buffer 20mM PO4 buffer, pH 7.6, with 250mM NaCl and 0.1% NaN3.
Concentration Batch dependent - please inquire should you have specific requirements

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by end user

Storage & Safety

Storage Aliquot and store at -20 deg C. Avoid repeated Freeze/Thaw cycles
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.

General Information

Biological Significance TrkA, apparent molecular weight 140 kDa, is a high affinity nerve growth factor (NGF). The Trk proto-oncogene family contains four members, TrkA, Tr kb, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates on tyrosine residues (Tyr490, Tyr674, Tyr675, Tyr751 and Tyr785) to activate multiple downstream effector proteins.

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Images

  • Western blot analysis using TrkA antibody (20R-TR013) | Western blot analysis of EGF-stimulated A431 cel lysate probed with anti-TrkA (2 ug/ml)
  • Immunohistochemical staining using TrkA antibody (20R-TR013) | Paraffin-embedded tissues of the hippocampal region (Fig. 1) and adrenal gland’s medulla (Fig. 2) were prepared using heat-induced epitope retrieval in citrate buffer, pH 6.0. Immunostaining was performed using a 1:200 dilution of Cat. No. 06-574, Anti-TrkA Reactivity was detected using the IHC-Select Detection Kit. Immunoreactivity is expressed in human brain regions of higher cognitive processes and inside the adrenal medulla without nuclear involvement.

Availability: In stock

Price: €772.19
Size: 200 ug
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