Troponin I protein (30-1232)
Purified native Human Troponin I protein
Overview
Overview
| Synonyms | Cardiac-specific troponin I protein, cTnl protein, Troponin I protein, TnI protein |
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| Species | Human |
| Protein Type | Native |
Specifications
| Source | Human Heart |
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| Grade & Purity | > 95% pure |
| Molecular Weight | 24 kDa |
| Form & Buffer | 8M Urea, 50mM Tris-HCl, 15mM beta-mercaptoethanol, 1mM EDTA |
| Concentration | 100 ug/ml |
Storage & Safety
| Storage | Store at 2-8 deg C for short term storage. For long term storage aliquot and store at -20 deg C |
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General Information
| Biological Significance | Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. |
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