Troponin I protein (Cardiac) (30-AT43)

Purified native Human Troponin I protein (Cardiac)

Species Human
Protein Type Native
Applications User optimized


Source Human cardiac tissue
Grade & Purity > 99% pure
Method of Purification Purified by ion-exchange and Tn-C affinity chromatography
Form & Buffer Supplied as a liquid in 8M Urea, 0.05M Tris HCl, 0.015M beta-mercaptoethanol, 2mM EDTA, pH 7.4

Storage & Safety

Storage Store at -20 degC to -70 deg C, avoid repeated freeze/thaw cycles
Biohazard Information Donor samples were tested and found to be negative for HBsAg, Anti-HIV-1/HIV-2, & HCV. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.

General Information

Biological Significance Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character.

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Availability: In stock

Price: €507.61
Size: 100 ug
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