Troponin I protein (Cardiac) (Dog) (30-1011)
Purified native Dog Troponin I protein (Cardiac)
Overview
Overview
| Synonyms | Cardiac-specific troponin I protein, cTnl protein, TnI protein, Troponin I protein |
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| Species | Dog |
| Protein Type | Native |
Specifications
| Source | Cardiac Tissue |
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| Grade & Purity | > 90% pure |
| Method of Purification | Troponin I protein was purified by Tn-C affinity chromatography. |
| Molecular Weight | 22-24 kDa |
| Form & Buffer | Supplied in 8M Urea, 50 mM Tris.HCl, 5 mM beta-mercaptoethanol, 2 mM EDTA, 0.5 mM CaCl2, pH 7.4 |
| Concentration | 0.25 - 2.0 mg/mL |
Storage & Safety
| Storage | Store at -25 deg C or below. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. |
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