Troponin I protein (Skeletal muscle) (30-AT48)

Purified native Human Troponin I protein (Skeletal muscle)

Species Human
Protein Type Native
Applications User optimized

Specifications

Source Human skeletal muscle
Grade & Purity > 95% pure
Form & Buffer 0.05M TRIS-HCl, pH 7.4, with 2mM EDTA, 8M Urea, and 15mM beta-mercaptoethanol.
Concentration Batch dependent - please inquire should you have specific requirements

Storage & Safety

Storage Aliquot and store at -20 deg C for short term storage, -70 deg C for long-term storage. Avoid repeated freeze/thaw cycles.
Biohazard Information Donor samples were tested and found to be negative for HBsAg, Anti-HIV-1/HIV-2, & HCV. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.

General Information

Biological Significance Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character.

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Availability: In stock

Price: €572.98
Size: 100 ug
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