Troponin I protein (Skeletal muscle) (30-AT48)
Purified native Human Troponin I protein (Skeletal muscle)
Overview
Overview
| Species | Human |
|---|---|
| Protein Type | Native |
| Applications | User optimized |
Specifications
| Source | Human skeletal muscle |
|---|---|
| Grade & Purity | > 95% pure |
| Form & Buffer | 0.05M TRIS-HCl, pH 7.4, with 2mM EDTA, 8M Urea, and 15mM beta-mercaptoethanol. |
| Concentration | Batch dependent - please inquire should you have specific requirements |
Storage & Safety
| Storage | Aliquot and store at -20 deg C for short term storage, -70 deg C for long-term storage. Avoid repeated freeze/thaw cycles. |
|---|---|
| Biohazard Information | Donor samples were tested and found to be negative for HBsAg, Anti-HIV-1/HIV-2, & HCV. Nonetheless caution should be used when handling this material as there is a margin of error in all tests. |
General Information
| Biological Significance | Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character. |
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