TROVE2 protein (GST tag) (His tag) (80-1383)

Purified recombinant TROVE2 (Ro60) protein (GST tag) (His tag)

Synonyms 60 KDa Ribonucleoprotein R0, Ro60 protein, Trove-2 protein, TROVE Domain Family Member 2 protein
Species Human
Protein Type Recombinant

Specifications

Residues 1-538 aa
Expression System E.coli
Grade & Purity > 80% pure
Method of Purification Purified using proprietary chromatographic techniques
Molecular Weight 93 kDA
Tag/Conjugate His-GST tag
Form & Buffer Supplied in 50mM Tris pH 7.0, 400mM NaCl, 10% glycerol, 1mM EDTA, 2mM DTT and 2mM CaCl2

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance TROVE2 is an RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules.
Expression TROVE2 expression is elevated during cellular reproduction. Tissue and Cell Localization: TROVE2 is found mainly in the cytoplasm of mammalian cells. It is localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Implications in Disease Diseases associated with TROVE2 include sjogren's syndrome, a chronic autoimmune disease in which the body's white blood cells destroy the exocrine glands, specifically the salivary and lacrimal glands, and congenital heart block, a problem affecting the heart's electrical system controling the rate and rhythm of heartbeats.
Post-Translational Modifications Ubiquitination occurs at Lys224, Lys227, Lys342 and Lys359. Phosphorylated upon DNA damage, probably by ATM or ATR.
Database Links Entrez Gene: 6738 Human, Omim: 600063 Human, SwissProt: P10155 Human, Unigene: 288178 Human

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