TSG101 protein (His tag) (80R-1296)
Purified recombinant Human TSG101 protein
|Synonyms||TSG10 protein, Tumor susceptibility gene 10 protein, TSG-101, Tumor susceptibility gene 101 ESCRT I complex subunit TSG101 protein, TSG 10 protein, TSG-101 protein, TSG 101, VPS 23 protein, VPS23 protein, Tumor susceptibility protein protein, TSG 101 protein, Tumor susceptibility protein isoform 3 protein, TSG 101 protein, VPS23., TSG101, Tumor susceptibility gene 101 protein|
Coomassie Blue stained SDS-PAGE of TSG101 protein (His tag) (80R-1296)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-145 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMAVS ESQLKKMVSK YKYRDLTVRE TVNVITLYKD LKPVLDSYVF NDGSSRELMN LTGTIPVPYR GNTYNIPICL WLLDTYPYNP PICFVKPTSS MTIKTGKHVD ANGKIYLPYL HEWKHPQSDL LGLIQVMIVV FGDEPPVFSR P|
|Grade & Purity||> 90% pure|
|Molecular Weight||20.7 kDa (181aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||TSG101(Tumor susceptibility gene 101) protein belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. This protein contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. Mutations and alternative splicing in this protein occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. Recombinant human TSG101 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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