Tyk2 antibody (10R-2027)
Mouse monoclonal Tyk2 antibody
|Synonyms||Monoclonal Tyk2 antibody, Anti-Tyk2 antibody, Tyk-2 antibody, Tyk 2 antibody, Tyk-2, Tyrosine kinase 2 antibody, Tyk 2 antibody, Tyk2, Tyk-2 antibody, Tyk 2|
|Immunogen||Tyk2 antibody was raised in Mouse using a purified recombinant fragment of Tyk2 expressed in E. coli as the immunogen.|
Western Blot analysis using Tyk2 antibody (10R-2027)
Western Blot showing TYK2 antibody used against truncated TYK2 recombinant protein (1) and Jurkat cell lysate (2).
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Tyk2 belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.|
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