TYK2 antibody (70R-12761)

Affinity purified Rabbit polyclonal TYK2 antibody

Synonyms Polyclonal TYK2 antibody, Anti-TYK2 antibody, non-receptor tyrosine-protein kinase TYK2 antibody, TYK-2, TYK-2 antibody, tyrosine kinase 2 antibody, JTK1 antibody, TYK 2 antibody, TYK 2, TYK2 antibody, TYK2
Cross Reactivity Human
Applications ICC, IF, WB
Immunogen TYK2 antibody was raised in rabbit using a recombinant fragment corresponding to a region within amino acids 680 and 1187 of TYK2

Images

Immunofluorescent staining using TYK2 antibody (70R-12761)

Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using TYK2 antibody at 1:200 dilution.

Specifications

Host Rabbit
Isotype IgG
Method of Purification TYK2 antibody was purified by antigen-affinity chromatography
Molecular Weight 134 kDa
Form & Buffer Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations IF:1:100-1:200, WB: 1:500-1:3000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

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Images

  • <div><font face=Calibri size=2>Immunofluorescent staining using TYK2 antibody (70R-12761)</font></div>     | Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using TYK2 antibody at 1:200 dilution.
  • <div><font face=Calibri size=2>Western blot analysis using TYK2 antibody (70R-12761)</font></div>     | Western blot analysis of 30 ug whole cell lysate (A:H1299; B:HeLa S3) using a 5 % SDS PAGE gel and TYK2 antibody at a dilution of 1:1000

Availability: In stock

Price: €323.11
Size: 100 ul
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