Ubc7 protein (30R-1045)
Purified recombinant Human Ubc7 protein
|Synonyms||Ubc7 (Ubiquitin Conjugating enzyme 7) protein, , Ubiquitin-conjugating enzyme E2 G1 protein, Ubiquitin conjugating enzyme E2G 1 (homologous to C protein, EC 220.127.116.11 protein, elegans UBC7) protein, Ubiquitin carrier protein G1 protein, UBE2G1 protein, Ubiquitin-conjugating enzyme E2L 3 UBC 7 protein, UBC7 protein, Ubiquitin conjugating enzyme E2G 1 protein, Ubiquitin protein ligase G1 protein, Ubiquitin conjugating enzyme E2G 1 (UBC7 homolog yeast) protein, Ubiquitin-protein ligase G1 protein, UBE2G protein, UBE 2G protein, Ubiquitin conjugating enzyme E2 G1 protein, E217K protein, Ubiquitin conjugating enzyme E2G 1 (UBC7 homolog C protein, UBC7 homolog yeast protein, elegans) antibody protein|
Coomassie Blue stained SDS-PAGE of Ubc7 protein (30R-1045)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA FRIEINFPAE YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK TDQVIQSLIA LVNDPQPEHP LRADLAEEYS KDRKKFCKNA EEFTKKYGEK RPVD|
|Grade & Purity||> 95% pure|
|Molecular Weight||17.9 kDa (154 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 50mM HEPES, pH7.5, containing 150mM NaCl, 1mM DTT, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Human Ubquitin-conjugating enzyme 7 (UbcH7) is a ubiquitin-conjugating enzyme (E2) mediating c-fos degradation, transcription factor NF-kB maturation, and human papilloma virus-mediated p53 and Myc protein degradation, in vitro. The ubiquitin-conjugating enzymes(E2s) are essential components of the post-translational protein ubiquitination pathway, mediating the transfer of activated ubiquitin to substrate proteins. The human UBE2L1-UBE2L4 gene could potentially encode different isoforms of the UbcH7. UBE2L3 gene, located at chromosome 22q11.2, is the only identical family member with introns and encodes a polypeptide sequence identical to that of UbcH7. UbcH7 (154 amino acids) was over-expressed in E. coli and purified by using conventional chromatography techniques.|
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