UBCH3 protein (His tag) (80R-2538)
Purified recombinant Human UBCH3 protein (His-tag)
Overview
Overview
| Synonyms | UBCH3, UBCH3 protein, Ubiquitin conjugating enzyme protein, UBCH 3 protein, UBCH-3 protein, UBCH 3, UBCH-3, Ubiquitin conjugating enzyme 3 protein |
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| Species | Human |
| Protein Type | Recombinant |
Specifications
| Expression System | E.coli |
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| Method of Purification | UBCH3 protein was purified using a a proprietary chromatographic technique. |
| Molecular Weight | 32.0 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied in 50 mM HEPES, 50 mM NaCl, pH 8.0, containing 1.0 mM DTT |
Storage & Safety
| Storage | Store at -80 deg C |
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General Information
| Biological Significance | UBCH3 is a class II enzyme, homologous to Cdc34 from Saccharomyces cerevisiae, and is important in the control of cell cycle and DNA replication. UBCH3/Cdc34 in association with different E3 complexes, including SCF, has been shown to target many different substrates for ubiquitination and degradation during cell division, signal transduction, and development. UBCH3 substrates that have been characterized include I?B, Wee1, ICERII gamma, p27Xic1. Additionally, substrates such as beta-catenin, p21, and is phosphorylated and ubiquitinylated in vivo. |
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