UNC13B antibody (70R-13408)

Affinity purified Rabbit polyclonal UNC13B antibody

Synonyms Polyclonal UNC13B antibody, Anti-UNC13B antibody, UNC13B antibody, UNCB 13, UNC13B, UNCB 13 antibody, UNC13 antibody, MUNC13 antibody, MGC133280 antibody, UNCB-13, Unc13h2 antibody, UNCB-13 antibody, hmunc13 antibody, MGC133279 antibody
Cross Reactivity Human
Applications ICC, IF, IHC-P, WB

Images

Immunofluorescent staining using UNC13B antibody (70R-13408)

Confocal immunofluorescence analysis (Olympus FV10i) of methanol-fixed HeLa, using UNC13B antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with (Red) at 1:2000.

Specifications

Host Rabbit
Isotype IgG
Method of Purification UNC13B antibody was purified by antigen-affinity chromatography
Molecular Weight 181 kDa
Form & Buffer Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations IF:1:100-1:1000, ICC:1:100-1:1000, IHC-P: 1:100-1:1000, WB: 1:500-1:3000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.

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Images

  • <div><font face=Calibri size=2>Immunofluorescent staining using UNC13B antibody (70R-13408)</font></div>     | Confocal immunofluorescence analysis (Olympus FV10i) of methanol-fixed HeLa, using UNC13B antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with (Red) at 1:2000.
  • <div><font face=Calibri size=2>Immunohistochemical staining using UNC13B antibody (70R-13408)</font></div>     | Immunohistochemical staining of paraffin-embedded A549 xenograft using UNC13B antibody at a dilution of 1:500
  • <div><font face=Calibri size=2>Western blot analysis using UNC13B antibody (70R-13408)</font></div>     | Western blot analysis of 30 ug of whole cell lysate (A: 293T) using a 5 % SDS PAGE gel and UNC13B antibody at a dilution of 1:500

Availability: In stock

Price: €323.11
Size: 100 ul
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