uPAR antibody (70R-11825)

Goat polyclonal uPAR antibody

Synonyms Polyclonal uPAR antibody, anti-uPAR antibody, URKR antibody, CD87 antibody, PLAUR antibody, Monocyte activation antigen Mo3 antibody, Urokinase plasminogen activator receptor antibody, CD_antigen antibody, UPAR antibody, CD87 antibody, Urokinase plasminogen activator surface receptor antibody, U-PAR antibody, MO3 antibody
Cross Reactivity Human
Applications IP, Neutralization, WB
Immunogen uPAR antibody was raised in Goat using E coli expressed recombinant human uPAR as the immunogen.

Specifications

Host Goat
Isotype IgG
Method of Purification uPAR antibody was purified by affinity chromatography
Form & Buffer Supplied in PBS buffer, pH 7.2, containing 50% glycerol, 1% BSA, 0.01% thimerosal
Concentration 500 ug/ml

Usage & Assay Information

Usage Recommendations IP: 5-10 ug/ml, Neutralization: 2-4 ug/ml, WB: 0.5-2 ug/ml

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance uPAR is a 55 kDa glycoprotein I-anchored surface receptor specific for urokinase plasminogen activator. Upon binding to uPAR, uPA converts the surface bound, large serum beta-globulin, plasminogen to plasmin. Plasmin, which is also designated fibrinolysin, is a trypsin-like enzyme that acts on Arg-Lys bonds and induces pericellular proteolysis in fibrin and fibrinogen, and thereby contributes to the systematic activation of the coagulation cascade. uPA and uPAR are known to be overexpressed in mesenchymal and epithelial tumor cells and are required for tumor invasion and metastasis.

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Availability: In stock

Price: €332.92
Size: 100 ug
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