Urokinase protein (Low MW) (30C-CP4014)
Purified native Human Urokinase protein (Low MW)
Overview
Overview
| Synonyms | URK protein, Human Urokinase protein, U Plasminogen Activator Protein protein, uPA protein, ATF protein |
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| Species | Human |
| Protein Type | Native |
| Applications | User optimized |
Specifications
| Source | Human urine |
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| Grade & Purity | > 95% pure |
| Molecular Weight | 33 kDa |
| Form & Buffer | Lyophilized from 50mM Tris-HCl, pH 7.4, with 100mM NaCl, 0.1% PEG 6000, and 200mM Mannitol. Reconstitute with 1 ml of deionized water. |
Usage & Assay Information
| Bioactivity | Specific activity is 160,000 IU/mg |
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Storage & Safety
| Storage | Aliquot and store at -20 DEG C. Avoid repeated Freeze/Thaw cycles. |
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| Biohazard Information | Donor samples were tested and found to be negative for HIV I/II, and HCV antibodies, and Hepatitis B surface antigen. Nonetheless caution should be used when handling this material as there is a margin of error in all tests. |
General Information
| Biological Significance | Urokinase , also called urokinase-type plasminogen activator (uPA), is a serine protease. It was originally isolated from human urine. The primary physiological substrate is plasminogen, activation of plasmin triggers a proteolysis cascade that, depending on the physiological environment, participates in thrombolysis or extracellular matrix degradation. This links urokinase to vascular diseases and cancer. |
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