Usp10 Blocking Peptide (33R-7850)
A synthetic peptide for use as a blocking control in assays to test for specificity of Usp10 antibody, catalog no. 70R-9733
Overview
Overview
| Synonyms | Usp10 control peptide, Usp10 antibody Blocking Peptide, Anti-Usp10 Blocking Peptide, ubiquitin specific peptidase 10 Blocking Peptide, MGC124997 Blocking Peptide, Usp10, Usp-10, Usp 10, Usp-10 Blocking Peptide, Usp 10 Blocking Peptide |
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| Protein Type | Synthetic |
| Applications | IHC, WB |
Specifications
| Residues | RDIRPGAAFEPTYIYRLLTVIKSSLSEKGRQEDAEEYLGFILNGLHEEML |
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| Molecular Weight | 87 kDa |
| Form & Buffer | Lyophilized powder. Add 100ul of distilled water for a final peptide concentration is 1 mg/ml. |
Storage & Safety
| Storage | Store at -20 deg C long term. Avoid repeat freeze-thaw cycles. |
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General Information
| Biological Significance | Usp10 is a hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, SNX3 and CFTR. It acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Usp10 does not deubiquitinate MDM2 and deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. |
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