VEGFC protein (Rat) (152s) (30R-AV006)
Purified recombinant Rat VEGFC protein (152s)
Overview
Overview
| Synonyms | Rat VEGF-C 152s protein, Vascular Endothelial Growth Factor C 152s protein |
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| Species | Rat |
| Protein Type | Recombinant |
| Applications | User optimized |
Specifications
| Expression System | Sf-9 insect cells |
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| Grade & Purity | > 90% pure |
| Molecular Weight | 18-24 kDa |
| Form & Buffer | Lyophilized (soluble in water and most aqueous buffers). Reconstitute in PBS or medium to a concentration not lower than 50ug/ml. |
Storage & Safety
| Storage | Ships ambient or refrigerated. Upon receipt store at -20°C. Avoid repeated freeze/thaw cycles. |
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| Endotoxin Levels | <0.1 ng per ug of VEGF-C152S |
General Information
| Biological Significance | VEGF-C152S is a point mutant generated by the replacement of the second conserved Cys residue of the recombinant processed VEGF-C by a Ser residue. VEGF-C152S is analog to the human VEGF-C156S mutant and only active toward VEGFR-3/FLT-4 but, unlike wild type VEGF-C, is unable to bind to and to activate signalling through VEGFR-2/kDaR. VEGF C152S was inactive in the vascular permeability assay and did not increase migration of the capillary endothelial cells, indicating that these VEGF-like effects of VEGF-C require VEGFR-2 binding. VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. The rat VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. |
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