VEGFC protein (Rat) (152s) (30R-AV006)

Purified recombinant Rat VEGFC protein (152s)

Synonyms Rat VEGF-C 152s protein, Vascular Endothelial Growth Factor C 152s protein
Species Rat
Protein Type Recombinant
Applications User optimized

Specifications

Expression System Sf-9 insect cells
Grade & Purity > 90% pure
Molecular Weight 18-24 kDa
Form & Buffer Lyophilized (soluble in water and most aqueous buffers). Reconstitute in PBS or medium to a concentration not lower than 50ug/ml.

Storage & Safety

Storage Ships ambient or refrigerated. Upon receipt store at -20°C. Avoid repeated freeze/thaw cycles.
Endotoxin Levels <0.1 ng per ug of VEGF-C152S

General Information

Biological Significance VEGF-C152S is a point mutant generated by the replacement of the second conserved Cys residue of the recombinant processed VEGF-C by a Ser residue. VEGF-C152S is analog to the human VEGF-C156S mutant and only active toward VEGFR-3/FLT-4 but, unlike wild type VEGF-C, is unable to bind to and to activate signalling through VEGFR-2/kDaR. VEGF C152S was inactive in the vascular permeability assay and did not increase migration of the capillary endothelial cells, indicating that these VEGF-like effects of VEGF-C require VEGFR-2 binding. VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. The rat VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein.

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Price From: Price: €178.32
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