VEGFR2 protein (Fc Chimera) (30R-AV017)

Purified recombinant Human VEGFR2 protein (Fc Chimera)

Synonyms VEGFR-2 protein, sKDR D1-7 protein, Protein-tyrosine kinase receptor Flk-1 protein, VEGFR-2 protein, CD309 protein, type III receptor tyrosine kinase protein, D1-7 proteinKDR D1-7 protein, FLK1 protein, KDR protein, Kinase insert domain receptor protein, VEGFR2-Fc Chimera
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Expression System Baculovirus
Grade & Purity > 90% pure
Method of Purification VEGFR2 protein (Fc Chimera) was purified by a proprietary chromatographic technique.
Molecular Weight 160 kDa
Tag/Conjugate Fc chimera
Form & Buffer Lyophilized from a solution of 1x PBS, pH 7.4.

Usage & Assay Information

Bioactivity The activity of sVEGFR-2/Fc was determined by its ability to inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells. The ED50 for this effect is typically 10-30 ng/ml.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze-thaw cycles.

General Information

Biological Significance Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (kDaR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes. All VEGF-receptors have seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular split tyrosine kinase domain. VEGFR-2 has a lower affinity for VEGF than the Flt-1 receptor, but a higher signaling activity. Mitogenic activity in endothelial cells is mainly mediated by VEGFR-2 leading to their proliferation.Differential splicing of the flt-1 gene leads to the formation of a secreted, soluble variant of VEGFR-1 (sVEGFR-1).

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Availability: In stock

Price: €164.65
Size: 10 ug
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