VEGFR3 antibody (10R-6599)

Rat monoclonal VEGFR3 antibody

Synonyms Monoclonal VEGFR3 antibody, Anti-VEGFR3 antibody, VEGFR 3 antibody, Flt-4 antibody, VEGFR3 antibody, VEGFR-3, VEGF receptor 3 antibody, vascular endothelial growth factor receptor 3 antibody, VEGF R3 antibody, Flt4 antibody, VEGFR-3 antibody, VEGFR3, VEGFR 3
Specificity Mouse
Applications FC, Functional Assay
Assay Information A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal /formance in the assay of interest

Specifications

Host Rat
Clone AFL4
Isotype IgG2a kappa
Method of Purification VEGFR3 antibody was purified by affinity chromatography.
Form & Buffer Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer.
Concentration 500 ug/ml

Usage & Assay Information

Usage Recommendations FC: = 1 ug/test

Storage & Safety

Storage Store at 2-8 deg C. Do not freeze. Protect from light.

General Information

Biological Significance The AFL4 monoclonal antibody reacts with the mouse VEGF receptor-3, also known as Flt-4. This 195 kDa molecule was identified as an endothelial-specific member of the receptor tyrosine kinase family. During early embryogenesis all endothelial cells express VEGFR-3, while in the adult tissues, VEGFR-3 expression disappears from the vascular endothelial cells and is observed only on the lymphatic endothelium. However, VEGFR-3 expression is induced in the adult tissue upon tumor implementation suggesting an important role for this receptor in the tumor angiogenesis. VEGF-C and VEGF-D bind to and activate VEGFR-3. AFL4 is an antagonist mAb.

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Price From: Price: €102.25
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