WIF1 protein (80R-4364)
Purified Recombinant WIF1 protein (His tagged)
Overview
Overview
| Synonyms | Wnt inhibitory factor 1 protein, Wif-1 protein, WIF-1 protein, AW107799 protein |
|---|---|
| Species | Mouse |
| Protein Type | Recombinant |
| Applications | SDS-PAGE |
Specifications
| Residues | 29-379 aa: GQPPEESLYL WIDAHQARVL IGFEEDILIV SEGKMAPFTH DFRKAQQRMP AIPVNIHSMN FTWQAAGQAE YFYEFLSLRS LDKGIMADPT VNVPLLGTVP HKASVVQVGF PCLGKQDGVA AFEVNVIVMN SEGNTILRTP QNAIFFKTCQ QAECPGGCRN GGFCNERRVC ECPDGFYGPH CEKALCIPRC MNGGLCVTPG FCICPPGFYG VNCDKANCST TCFNGGTCFY PGKCICPPGL EGEQCELSKC PQPCRNGGKC IGKSKCKCPK GYQGDLCSKP VCEPGCGAHG TCHEPNKCQC REGWHGRHCN KRYGASLMHA PRPAGAGLER HTPSLKKAED RRDPPESNYI WVEHHHHHH |
|---|---|
| Expression System | Insect cells |
| Grade & Purity | > 90% pure |
| Molecular Weight | 39.4 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied in liquid form in 20mM MES (pH5.5) containing 1mM DTT, 1mM PMSF, 30% glycerol. |
| Concentration | 1 mg/ml |
Storage & Safety
| Storage | Store at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 or -70 deg C. Avoid repeated freezing and thawing cycles. |
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| Endotoxin Levels | < 1.0 EU per 1 microgram of protein (determined by LAL method) |
General Information
| Biological Significance | WIF1, also known as wnt inhibitory factor 1, is a secreted protein that binds to Wnt proteins and inhibits their activities. This protein signaling plays a pivotal role in skeletal development and in the control of cartilage and bone turnover. Also, WIF1 is present in fish, amphibia and mammals, and is expressed during Xenopus and zebrafish development in a complex pattern that includes paraxial presomitic mesoderm, notochord, branchial arches and neural crest derivatives. |
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