WWOX protein (His tag) (80R-1157)
Purified recombinant Human WWOX protein
|Synonyms||MGC55975 protein, SDR41C1 protein, D16S432E protein, FRA16D protein, Short chain dehydrogenase/reductase family 41C protein, Putative oxidoreductase protein, WW domain containing oxidoreductase 5330426P09Rik protein, member 1 protein, WW domain-containing protein WWOX., FOR protein, WOX1 protein, PRO0128 protein, PRO0128 protein, HHCMA56 protein, zgc:55975 protein, 9030416C10Rik protein, WW domain containing oxidoreductase protein, EC 1.1.1.- Fragile site FRA16D Oxireductase protein|
Coomassie Blue stained SDS-PAGE of WWOX protein (His tag) (80R-1157)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-234 amino acids: MGSSHHHHHH SSGLVPRGSH MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG KRKRVAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK PTTRQRYDGS TTAMEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH VILACRNMAR ASEAVSRILE EWQQGAATTV YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL SERLIQERLG SQSG|
|Grade & Purity||> 85% pure|
|Molecular Weight||28.3 kDa (254aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||WWOX, also known as WW domain containing oxidoreductase, is a proapoptotic protein and a tumor suppressor protein. WWOX is found in all eukaryotes and plays an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This protein may function synergistically with TP53/p53 to control genotoxic stress-induced cell death. It also plays a role in tumor necrosis factor (TNF)-mediated cell death. Recombinant human WWOX protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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