WWOX protein (His tag) (80R-1157)
Purified recombinant Human WWOX protein
Overview
Overview
| Synonyms | MGC55975 protein, SDR41C1 protein, D16S432E protein, FRA16D protein, Short chain dehydrogenase/reductase family 41C protein, Putative oxidoreductase protein, WW domain containing oxidoreductase 5330426P09Rik protein, member 1 protein, WW domain-containing protein WWOX., FOR protein, WOX1 protein, PRO0128 protein, PRO0128 protein, HHCMA56 protein, zgc:55975 protein, 9030416C10Rik protein, WW domain containing oxidoreductase protein, EC 1.1.1.- Fragile site FRA16D Oxireductase protein |
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| Species | Human |
| Protein Type | Recombinant |
| Applications | SDS-PAGE |
Images
Coomassie Blue stained SDS-PAGE of WWOX protein (His tag) (80R-1157)
Figure annotation denotes ug of protein loaded and % gel used.
Specifications
| Residues | 1-234 amino acids: MGSSHHHHHH SSGLVPRGSH MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG KRKRVAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK PTTRQRYDGS TTAMEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH VILACRNMAR ASEAVSRILE EWQQGAATTV YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL SERLIQERLG SQSG |
|---|---|
| Expression System | E.coli |
| Grade & Purity | > 85% pure |
| Molecular Weight | 28.3 kDa (254aa), confirmed by MALDI-TOF. |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol. |
| Concentration | 1 mg/ml |
Storage & Safety
| Storage | Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | WWOX, also known as WW domain containing oxidoreductase, is a proapoptotic protein and a tumor suppressor protein. WWOX is found in all eukaryotes and plays an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This protein may function synergistically with TP53/p53 to control genotoxic stress-induced cell death. It also plays a role in tumor necrosis factor (TNF)-mediated cell death. Recombinant human WWOX protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography. |
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