YARS protein (GST tag) (80R-3070)

Purified recombinant YARS protein (GST tag)

Synonyms Tyrosyl tRNA ligase protein, TyrRS protein, Tyrosyl tRNA synthetase cytoplasmic protein
Species Human
Protein Type Recombinant
Applications ELISA, SDS-PAGE, WB

Specifications

Expression System E.coli
Grade & Purity > 95% pure
Molecular Weight 85 kDa
Tag/Conjugate GST tag
Form & Buffer Supplied in liquid form in 6M guanidine hydrochloride and 20mM Tris buffer

Storage & Safety

Storage Store at 4 deg C in a working aliquot for 1 week. For long term storage, aliquot and freeze at -20 to -80 deg C, avoid repeat freeze/thaw cycles

General Information

Biological Significance YARS catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC). CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.

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Availability: In stock

Price: €183.23
Size: 50 ug
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