Yellow Fever Virus NS1 protein (80-1547)
Purified Recombinant Yellow Fever Virus NS1 protein (His tag)
Overview
Overview
| Synonyms | Yellow Fever Virus NS1 antigen, YFV NS1 antigen, YFV NS1 protein, YFV Nonstructural protein, Yellow Fever Virus Nonstructural protein |
|---|---|
| Species | Viral |
| Protein Type | Recombinant |
Specifications
| Expression System | 293 cells |
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| Grade & Purity | > 95% pure |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied in DPBS, pH 7.4 |
| Concentration | 500 ug/ml |
Storage & Safety
| Storage | Store at -80 deg C |
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General Information
| Product Use | Yellow Fever Virus NS1 protein for use in the research laboratory |
|---|---|
| Biological Significance | The Yellow Fever Virus NS1 protein is a native hexameric presentation. The hexamer is believed to be the biologically active form of NS1 involved in key aspects of yellow fever pathogenesis. The resultant Yellow Fever Virus NS1 protein is purified to a high degree, is in its native folding state, and possesses all post-translational modifications. |
| Implications in Disease | Yellow fever begins after an incubation period of three to six days. Most cases only cause a mild infection with fever, headache, chills, back pain, fatigue, loss of appetite, muscle pain, nausea, and vomiting. In these cases, the infection lasts only three to four days. In 15 percent of cases, however, people enter a second, toxic phase of the disease with recurring fever, this time accompanied by jaundice due to liver damage, as well as abdominal pain. Bleeding in the mouth, the eyes, and the gastrointestinal tract will cause vomit containing blood. The toxic phase is fatal in about 20% of cases, making the overall fatality rate for the disease 3%. In severe epidemics, the mortality may exceed 50%. Surviving the infection provides lifelong immunity, and normally there is no permanent organ damage. |
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