ZC3H8 antibody was raised in rabbit using a recombinant protein fragment contain a sequence corresponding to a region within amino acids 31 and 254 of ZC3H8
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General Information
Biological Significance
Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region of the GATA3 gene. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.