Zika virus envelope protein (30-1932)
Recombinant Zika virus envelope protein
Overview
Overview
| Synonyms | Zika ENV protein, Zika virus E protein, Zika envelope protein, Zika protein, Zika virus antigen, recombinant Zika protein, recombinant Zika antigen, Zika virus envelope antigen, recombinant Zika envelope protein, recombinant Zika envelope antigen, ZIKV protein, ZIKV antigen, ZIKV envelope |
|---|---|
| Species | Viral |
| Protein Type | Recombinant |
| Applications | ELISA, Lateral Flow |
| Assay Information | Matching Zika virus envelope antibodies available: 10-2712, 10-2713, 10-2714, 10-2715 |
Images
SDS-PAGE analysis of Zika virus envelope protein (30-1932)
Coomassie stained SDS-PAGE gel showing Zika envelope protein migrating at approximately 50 kDa.
Specifications
| Residues | Zika virus envelope (E protein) comprising amino acids 291-690. |
|---|---|
| Expression System | Insect cells |
| Source | Baculovirus derived recombinant Zika envelope |
| Grade & Purity | > 85% pure |
| Molecular Weight | 50 kDa |
| Form & Buffer | Supplied as liquid in PBS buffer, pH 7.4 with 0.05% sodium azide |
Storage & Safety
| Storage | Store in small aliquots at -20 deg C. Avoid repeated freeze thaw cycles. |
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General Information
| Biological Significance | Zika virus spreads to people primarily through the bite of an infected Aedes species mosquito, but it can also be sexually transmitted. Zika virus was first discovered in 1947 and is named after the Zika Forest in Uganda. In 1952, the first human cases of Zika were detected. Zika virus has become a highly researched disease due to increase in incidences from 2007 to 2016, when the virus spread eastward, across the Pacific Ocean to the Americas. In 2015–16 Zika virus epidemic reached pandemic levels. The Zika envelope (E) protein composes the majority of the virion surface and it is involved with replication, such as host cell binding and membrane fusion. |
|---|---|
| Implications in Disease | The symptoms of Zika infection vary from non-existant to visible rash, fever, headaches and conjunctivitis. It is usually non life threatening, but has been associated to microcephaly in unborn fetuses when passed by an infected pregnant mother. |
| Sequence Information | The sequence of the envelope protein is derived from the African strain (all strains share very high identity in this region). |
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