Zika virus NS1 protein (30-1931)
Recombinant Zika virus NS1 protein
Overview
Overview
| Synonyms | Zika protein, Zika virus antigen, recombinant Zika protein, recombinant Zika antigen, Zika NS1 protein, Zika virus NS1 antigen, recombinant Zika NS1 protein, recombinant Zika NS1 antigen, Zika virus Non-Structural protein 1, Zika Non Structural protein 1, ZIKV protein, ZIKV antigen, ZIKV NS1 |
|---|---|
| Species | Viral |
| Protein Type | Recombinant |
| Applications | ELISA, Lateral Flow |
| Assay Information | Matching Zika virus NS1 antibodies available: 10-2707, 10-2708, 10-2709, 10-2710, 10-2711 |
Images
SDS-PAGE analysis of Zika virus NS1 protein (30-1931)
Coomassie stained SDS-PAGE gel showing Zika virus NS1 protein migrating at approximately 50 kDa.
Specifications
| Residues | Zika virus NS1 comprising amino acids 792-1144. |
|---|---|
| Expression System | Insect cells |
| Source | Baculovirus derived recombinant Zika NS3 |
| Grade & Purity | > 90% pure |
| Molecular Weight | 50 kDa |
| Form & Buffer | Supplied as liquid in PBS buffer, pH 7.4 with 0.05% sodium azide |
Storage & Safety
| Storage | Store in small aliquots at -20 deg C. Avoid repeated freeze thaw cycles. |
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General Information
| Biological Significance | Zika virus (ZIKV), a Flaviviridae family member transmitted to humans by mosquitoes of the genus Aedes, was first isolated in Africa in 1947. It has been found to commonly circulate in tropical regions in Africa and Asia. As a member of the Flaviviridae family, ZIKV has a single positive sense RNA genome, which is initially translated as a single polyprotein which is then cleaved post-translationally into three structural proteins (C, PrM or M, and E) and seven nonstructural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5). NS1 is required for viral replication inside cells and is also secreted into the extracellular space as a hexameric lipoprotein particle, which is involved in immune evasion and pathogenesis by interacting with components from both the innate and adaptive immune systems. |
|---|---|
| Implications in Disease | There is growing evidence that Zika virus infections may be linked to fetal and newborn microcephaly and serious neurological complications, such as Guillain Barré syndrome. NS1 is the major antigenic marker for viral infection. To date, no clinically approved vaccines or therapeutics are available to prevent and control of Zika virus infection. |
| Sequence Information | Zika NS1 is a highly conserved region of the virus. |
| Post-Translational Modifications | Post translationally, NS1 is glycosylated and associates with lipids forming a homodimer inside the cells. It is necessary for viral replication and late in infection. |
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