Zika virus NS1 protein (30-1936)
Recombinant Zika virus NS1 protein
Overview
Overview
| Synonyms | Zika NS1 protein, Zika protein, recombinant Zika NS1 protein, ZIKV NS1, Zika virus Nonstructural protein 1, Zika virus Non-structural protein 1, Zika virus antigen, recombinant Zika protein, recombinant Zika antigen, Zika virus NS1 antigen, recombinant Zika NS1 antigen, ZIKV protein, ZIKV antigen |
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| Species | Viral |
| Protein Type | Recombinant |
| Applications | ELISA, Lateral Flow, WB |
| Assay Information | This protein binds to Zika converted human serum polyclonal antibodies and cross reacts with Dengue virus converted human serum polyclonal antibodies. |
Specifications
| Expression System | E.coli |
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| Grade & Purity | > 95% pure |
| Method of Purification | Purified by aqueous solvent extraction and preparative electrophoresis to > 95% purity |
| Molecular Weight | 44 kDa |
| Form & Buffer | Supplied as liquid in 50 mM NaPO4, pH 7.5 |
Usage & Assay Information
| Usage Recommendations | ELISA: 1-2 ug/ml protein range for titering Dengue virus converted human polyclonal antibodies. Lateral Flow: 1-2mg/ml (1-2ul/cm) |
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Storage & Safety
| Storage | Store in small aliquots at -70 deg C. Avoid repeated freeze thaw cycles. |
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General Information
| Biological Significance | Zika virus was first discovered in Ughanda in 1947 in monkeys infected by the virus through bites from of infected Aedes species mosquitos. Zika virus has become a highly researched disease due to increase in incidences from 2007 to 2016, when the virus spread eastward, across the Pacific Ocean to the Americas. In 2015–16 Zika virus epidemic reached pandemic levels. The Zika NS1 protein composes the majority of the virion surface and it is involved with replication, such as host cell binding and membrane fusion. |
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| Implications in Disease | Many people infected with Zika virus will have mild or no symptoms while others will have fever, rash, joint pain, or conjunctivitis. People rarely die from Zika virus. Pregnant woman can pass Zika virus to her fetus causing microcephaly and other severe fetal brain defects. |
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